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Trade Name	Drug Name	Approved	Patent Expires	Indication
Opgenra	Eptotermin alfa	2009-02-19		Spondylolisthesis , Tibial fractures
Osigraft	Eptotermin alfa	2001-05-17		Spondylolisthesis , Tibial fractures

Clinical Trials

Therapeutic Areas:

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Status:

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Phases:

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Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

Eptotermin alfa

spondylolisthesis

,

intervertebral disc degeneration

,

,

hyperlipidemias

,

gastrointestinal stromal tumors

,

,

iron-deficiency anemia

,

iron deficiencies

,

,

,

,

small cell lung carcinoma

,

healthy volunteers/patients

,

,

primary myelofibrosis

,

myeloid leukemia acute

,

myeloid leukemia

,

,

hepatocellular carcinoma

,

,

plexiform neurofibroma

,

neurofibromatoses

,

,

,

,

chronic obstructive pulmonary disease

,

,

triple negative breast neoplasms

,

,

,

essential thrombocythemia

,

polycythemia vera

,

,

,

lupus nephritis

,

,

inflammatory breast neoplasms

,

prostatic neoplasms

,

precursor cell lymphoblastic leukemia-lymphoma

,

precursor t-cell lymphoblastic leukemia-lymphoma

,

b-cell chronic lymphocytic leukemia

,

lymphoid leukemia

,

,

wiskott-aldrich syndrome

,

bcr-abl positive chronic myelogenous leukemia

,

,

,

hyperlipoproteinemia type ii

,

organ transplantation

,

homozygous familial hypercholesterolemia

,

cryopyrin-associated periodic syndromes

,

myelodysplastic syndromes

,

,

liver transplantation

,

thrombocytopenic purpura idiopathic

,

thrombocytopenic purpura

,

,

parkinson disease

,

,

,

juvenile arthritis

,

,

,

,

hepatitis b virus

,

,

,

,

vision disorders

,

,

pituitary acth hypersecretion

,

acth-secreting pituitary adenoma

,

,

acute coronary syndrome

,

,

,

pulmonary eosinophilia

,

pancreatic neoplasms

,

,

,

kidney transplantation

,

,

hypercholesterolemia

,

cardiovascular diseases

,

atherosclerosis

,

chronic kidney failure

,

kidney diseases

,

thrombocytopenia

,

,

breast neoplasms

,

,

renal insufficiency

,

,

,

,

chronic renal insufficiency

,

,

renal replacement therapy

,

drug-related side effects and adverse reactions

,

heart transplantation

,

polycystic kidney diseases

,

autosomal dominant polycystic kidney

,

,

,

cystic fibrosis

,

pseudomonas infections

,

type 2 diabetes mellitus

,

diabetes mellitus

,

multiple myeloma

,

plasma cell neoplasms

,

transplantation

,

cytomegalovirus infections

,

communicable diseases

,

,

healthy volunteers/patients

,

hepatic insufficiency

,

esophageal neoplasms

,

,

,

small cell lung carcinoma

,

pancreatic ductal carcinoma

,

multiple myeloma

,

plasma cell neoplasms

,

bronchiolitis obliterans syndrome

,

congenital abnormalities

,

chromosome aberrations

,

brain stem neoplasms

,

chronic hepatitis c

,

chronic hepatitis

,

,

,

medulloblastoma

,

,

,

choroid plexus neoplasms

,

primitive neuroectodermal tumors

,

,

,

neuroepithelial neoplasms

,

ganglioneuroblastoma

,

neuroectodermal tumors

,

phenylketonurias

,

precursor t-cell lymphoblastic leukemia-lymphoma

,

nasopharyngeal carcinoma

,

ureteral neoplasms

,

pelvic neoplasms

,

adenoid cystic carcinoma

,

metabolic syndrome

,

follicular lymphoma

,

,

pancreatic neoplasms

,

kidney neoplasms

,

,

prostatic neoplasms

,

,

,

head and neck neoplasms

,

neurofibromatoses

,

,

liver neoplasms

,

,

,

neurofibromatosis 1

,

plexiform neurofibroma

,

systemic scleroderma

,

diffuse scleroderma

,

b-cell chronic lymphocytic leukemia

,

,

hematologic neoplasms

,

endometrial neoplasms

,

neuroendocrine carcinoma

,

central nervous system neoplasms

,

ovarian neoplasms

,

mantle-cell lymphoma

,

urinary bladder neoplasms

,

squamous cell carcinoma

,

uterine cervical neoplasms

,

myelodysplastic syndromes

,

non-hodgkin lymphoma

,

nervous system neoplasms

,

hypereosinophilic syndrome

,

systemic mastocytosis

,

,

uveal neoplasms

,

squamous cell carcinoma of head and neck

,

t-cell lymphoma

,

transitional cell carcinoma

,

primary myelofibrosis

,

,

graft vs host disease

,

adenocarcinoma of lung

,

diffuse intrinsic pontine glioma

,

disease progression

,

oligodendroglioma

,

neurofibromatosis 2

,

acoustic neuroma

,

,

hodgkin disease

,

islet cell carcinoma

,

hematologic diseases

,

myeloid leukemia accelerated phase

,

,

mast-cell leukemia

,

,

germ cell and embryonal neoplasms

,

,

anaplastic thyroid carcinoma

,

t-cell lymphoma peripheral

,

waldenstrom macroglobulinemia

,

castration-resistant prostatic neoplasms

,

,

cholangiocarcinoma

,

chronic disease

,

large-cell lymphoma anaplastic

,

plasma cell granuloma

,

,

,

,

,

gouty arthritis

,

endocrine gland neoplasms

,

,

urogenital neoplasms

,

male genital diseases

,

prostatic diseases

,

abdominal neoplasms

,

male genital neoplasms

,

genital diseases

,

sjogren's syndrome

,

retinitis pigmentosa

,

,

,

giant cell tumors

,

pigmented villonodular synovitis

,

giant cell tumor of tendon sheath

,

choroidal neovascularization

,

pathologic neovascularization

,

hemangioblastoma

,

von hippel-lindau disease

,

inflammatory breast neoplasms

,

invasive hydatidiform mole

,

multidrug-resistant tuberculosis

,

local neoplasm recurrence

,

t-cell lymphoma cutaneous

,

peutz-jeghers syndrome

,

acute coronary syndrome

,

st elevation myocardial infarction

,

malignant mesothelioma

,

,

type 1 diabetes mellitus

,

,

intestinal neoplasms

,

testicular neoplasms

,

,

brain stem infarctions

,

,

sturge-weber syndrome

,

klippel-trenaunay-weber syndrome

,

neurofibrosarcoma

,

nerve sheath neoplasms

,

carcinoma in situ

,

breast diseases

,

multiple hamartoma syndrome

,

,

urologic neoplasms

,

fallopian tube neoplasms

,

t-cell leukemia

,

localized scleroderma

,

myelomonocytic leukemia chronic

,

myelomonocytic leukemia acute

,

myelomonocytic leukemia juvenile

,

,

,

ovarian epithelial carcinoma

,

sickle cell anemia

,

streptococcus agalactiae

,

colorectal neoplasms

,

myeloid leukemia acute

,

,

,

neoplasm metastasis

,

brain neoplasms

,

hepatocellular carcinoma

,

,

thyroid neoplasms

,

thyroid diseases

,

chronic urticaria

,

,

large b-cell lymphoma diffuse

,

b-cell lymphoma

,

,

triple negative breast neoplasms

,

,

colonic neoplasms

,

,

carcinoid tumor

,

pulmonary arterial hypertension

,

familial primary pulmonary hypertension

,

,

gastrointestinal neoplasms

,

stomach neoplasms

,

rectal neoplasms

,

,

meningococcal meningitis

,

meningococcal infections

,

rheumatoid arthritis

,

organ transplantation

,

graft rejection

,

digestive system neoplasms

,

cutaneous malignant melanoma

,

,

lymphangioleiomyomatosis

,

lupus nephritis

,

,

hypersensitivity

,

peanut hypersensitivity

,

multiple sclerosis

,

relapsing-remitting multiple sclerosis

,

interstitial lung diseases

,

,

lung transplantation

,

malignant carcinoid syndrome

,

serotonin syndrome

,

food hypersensitivity

,

psoriatic arthritis

,

,

muscular atrophy

,

spinal muscular atrophy

,

,

,

,

idiopathic pulmonary fibrosis

,

pulmonary fibrosis

,

,

chronic inducible urticaria

,

infectious skin diseases

,

bacterial skin diseases

,

,

,

myeloid leukemia

,

,

bcr-abl positive chronic myelogenous leukemia

,

breast neoplasms

,

,

,

non-small-cell lung carcinoma

,

renal cell carcinoma

,

,

kidney transplantation

,

philadelphia chromosome

,

lymphoid leukemia

,

neuroendocrine tumors

,

gastrointestinal stromal tumors

,

precursor cell lymphoblastic leukemia-lymphoma

,

,

myeloid leukemia chronic-phase

,

liver transplantation

,

renal insufficiency

,

tuberous sclerosis

,

chronic kidney failure

,

heart transplantation

,

kidney diseases

,

islet cell adenoma

,

,

,

macular degeneration

,

,

,

,

autosomal dominant polycystic kidney

,

communicable diseases

,

polycystic kidney diseases

,

,

diabetes mellitus

,

tick-borne encephalitis

,

,

immunosuppression therapy

,

cytomegalovirus infections

,

,

large cell carcinoma

,

vascular diseases

,

,

,

vision disorders

,

,

type 2 diabetes mellitus

,

cross-sectional studies

,

,

polyomavirus infections

,

cryopyrin-associated periodic syndromes

,

polycythemia vera

,

,

,

systolic heart failure

,

myocardial infarction

,

,

,

inferior wall myocardial infarction

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